2'-Deoxyadenosine-5'-monophosphate disodium salt

Names

[ Name ]:
2'-Deoxyadenosine-5'-monophosphate disodium salt

[Synonym ]:
MFCD00065990
disodium 2'-deoxyadenosine 5'-monophosphate
5'-Adenylic acid, 2'-deoxy-, sodium salt (1:2)
Disodium 2'-deoxy-5'-O-phosphonatoadenosine
EINECS 220-873-3

Biological Activity

[Description]:

2′-Deoxyadenosine 5′-monophosphate disodium, a nucleic acid AMP derivative, is a deoxyribonucleotide found in DNA. 2′-Deoxyadenosine 5′-monophosphate disodium can be used to study adenosine-based interactions during DNA synthesis and DNA damage[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

2′-Deoxyadenosine 5′-monophosphate (dAMP) is incorporated into Caco-2 cells in a time-dependent manner. The uptake of 2′-Deoxyadenosine 5′-monophosphate is increased with a drop in pH, suggesting that 2′-Deoxyadenosine 5′-monophosphate transport activity might be linked to the protons. 2′-Deoxyadenosine 5′-monophosphate uptake by Caco-2 cells is pH- and Na+-dependent[1].

[References]

[1]. Katsuya Narumi, et al. Mutual role of ecto-5'-nucleotidase/CD73 and concentrative nucleoside transporter 3 in the intestinal uptake of dAMP. PLoS One. 2019 Oct 21;14(10):e0223892.

[2]. V Duarte, et al. Insertion of dGMP and dAMP during in vitro DNA synthesis opposite an oxidized form of 7,8-dihydro-8-oxoguanine. Nucleic Acids Res. 1999 Jan 15;27(2):496-502.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₂N₅Na₂O₆P

[ Molecular Weight ]:
375.185

[ Exact Mass ]:
375.032074

[ PSA ]:
181.31000

[ LogP ]:
0.62380

[ Storage condition ]:
−20°C

[ Water Solubility ]:
H2O: 50 mg/mL, clear, colorless

MSDS

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Safety Information

[ Hazard Codes ]:
Xi,Xn

[ Risk Phrases ]:
36/37/38-20/21/22

[ Safety Phrases ]:
S22-S26-S36-S24/25-S37/39

[ WGK Germany ]:
3