Anticancer agent 102

Anticancer agent 102 is a derivative of tetracaine. Anticancer agent 102 has anti-cancer activity. Anticancer agent 102 induces apoptosis[1].

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Anticancer agent 102 (compound 2s; 24 and 48 h) 具有抗肿瘤活性，对 Colo-205 和 HepG2 细胞的 IC50 值分别为 299.4 μM 和 62.9 μM[ 1]. Anticancer agent 102 (25 µM 和 50 µM; 24 h) 下调了 Colo-205 细胞中凋亡蛋白 PI3K 和 FoXO3a 的表达水平，上调了 PTEN 和 FoXO1 的表达水平。Anticancer agent 102 (24 h) 上调 Bax 表达并诱导 HepG2 细胞系中的 caspase-3 依赖性细胞凋亡。 Cell Viability Assay[ 1] Cell Line: Colo-205 and HepG2 cells Concentration: 12.5, 25, 50, 100, 200, and 400 µM Incubation Time: 24 and 48 hours Result: Inhibited cell growth in a dose-dependent manner. Western Blot Analysis[ 1] Cell Line: Colo-205 cells Concentration: 25 µM and 50 µM Incubation Time: 24 hours Result: down-regulated the expression level of apoptotic protein PI3K and FoXO3a, up-regulated the expression level of PTEN and FoXO1 in Colo-205 cells.

[1]. M İhsan Han, et al. Design, Synthesis, and Anticancer Evaluation of Novel Tetracaine Hydrazide-Hydrazones. ACS Omega. 2023 Feb 28;8(10):9198-9211.