BI‑3231

Names

[ Name ]:
BI‑3231

Biological Activity

[Description]:

BI 3231 is a potent and selective hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13) inhibitor, with IC50s of 1 and 13 nM for hHSD17B13 and mHSD17B13, respectively. BI 3231 has the potential for the research of nonalcoholic steatohepatitis (NASH) and other liver diseases[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[Target]

hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13)[1]

[In Vitro]

BI 3231 在肝微粒体中表现出高代谢稳定性，在肝细胞中表现出中等代谢稳定性[1]。

[In Vivo]

BI 3231 从血浆中迅速清除，但在 48 h 内仍保持相当大的肝脏暴露[1]。

[References]

[1]. Thamm S, et, al. Discovery of a Novel Potent and Selective HSD17B13 Inhibitor, BI-3231, a Well-Characterized Chemical Probe Available for Open Science. J Med Chem. 2023 Feb 2.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₄F₂N₄O₃S

[ Molecular Weight ]:
380.37

Related Compounds

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