WM-586

Names

[ Name ]:
WM-586

Biological Activity

[Description]:

WM-586 is a covalent WDR5 inhibitor that disrupts the binding of WDR5 to MYC. WM-586 specifically decreases cellular WDR5 and MYC interaction with the IC50 of 101 nM in HTRF assay[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Histone Methyltransferase

[Target]

IC50: 101 nM (WDR5 and MYC interaction)[1]

[References]

[1]. Ding J, et al. Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction. ACS Chem Biol. 2023 Jan 20;18(1):34-40.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₀F₃N₅O₃S

[ Molecular Weight ]:
467.46

Related Compounds

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