Dibutyl squarate

Names

[ Name ]:
Dibutyl squarate

[Synonym ]:
MFCD00037150
3,4-di-n-Butoxy-3-cyclobutene-1,2-dione
3,4-Dibutoxy-3-cyclobutene-1,2-dione
squaric acid dibutyl ester
Squaric acid di-n-butyl ester
SADBE
3-Cyclobutene-1,2-dione, 3,4-dibutoxy-
Di-n-butyl squarate
1,2-dibutyl squarate
dibutylsquarate
1,2-dibutoxy-1-cyclobutene-3,4-dione
Dibutyl squarate
3,4-dibutoxycyclobut-3-ene-1,2-dione
3,4-di-n-butyl-3-cyclobutene-1,2-dione
Squaric acid dibutylester

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
353.2±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₂H₁₈O₄

[ Molecular Weight ]:
226.269

[ Flash Point ]:
157.2±30.7 °C

[ Exact Mass ]:
226.120514

[ PSA ]:
52.60000

[ LogP ]:
1.97

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.477

[ Water Solubility ]:
INSOLUBLE

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H317-H319-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R36/37/38;R42/43

[ Safety Phrases ]:
S26-S27-S36/37/39-S45

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
GU1772066

[ HS Code ]:
2914509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914509090

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Adjunctive trichloroacetic acid therapy enhances squaric acid response to verruca vulgaris.

Journal. of. Drugs in. Dermatology. 11(10) , 1228-30, (2012)

Squaric acid dibutyl ester (SADBE) is a commonly used treatment for verruca vulgaris of childhood. Few studies, however, have examined the role of SADBE in combination with other topical therapies for...

Biphenyls as potent vitronectin receptor antagonists. Part 3: Squaric acid amides.

Bioorg. Med. Chem. Lett. 17(22) , 6151-4, (2007)

Vitronectin receptor (alpha(V)beta(3)) antagonists have been implicated as a possible new treatment of restenosis following balloon angioplasty. In this work we investigate a series of novel arginine ...

Chronic delayed-type hypersensitivity reaction as a means to treat alopecia areata.

Clin. Exp. Immunol. 135(3) , 398-408, (2004)

The acute phase of alopecia areata (AA) is characterized by an increase in CD44v3+ and CD44v10+ skin-infiltrating leucocytes (SkIL). Induction of a contact eczema, one of the therapeutic options in AA...