CPD-1224

Names

[ CAS No. ]:
2891620-68-9

[ Name ]:
CPD-1224

Biological Activity

[Description]:

CPD-1224 is an orally active derivative of ALK inhibitors to cereblon ligands. CPD-1224 targets to EML4-ALK oncogenic fusions, and degrades ALK and mutant L1196M/G1202R[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK

[References]

[1]. Gao Y, et al. Catalytic Degraders Effectively Address Kinase Site Mutations in EML4-ALK Oncogenic Fusions. J Med Chem. 2023 Apr 10.  

Chemical & Physical Properties

[ Molecular Formula ]:
C43H47ClN8O7S

[ Molecular Weight ]:
855.40

Related Compounds

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