JAK-IN-30

Names

[ CAS No. ]:
2891469-99-9

[ Name ]:
JAK-IN-30

Biological Activity

[Description]:

JAK-IN-30 (compound 31) is a water-soluble JAK inhibitor with IC50 values of 2, 15, 18 and 2 nM for JAK2, JAK1, JAK3 and TYK2, respectively. JAK-IN-30 has research potential for dry eye disease (DED)[1].

[Related Catalog]:

Signaling Pathways >> JAK/STAT Signaling >> JAK
Signaling Pathways >> Epigenetics >> JAK
Signaling Pathways >> Stem Cell/Wnt >> JAK
Research Areas >> Inflammation/Immunology

[Target]

JAK1:15 nM (IC50)

JAK2:2 nM (IC50)

JAK3:18 nM (IC50)

Tyk2:2 nM (IC50)


[References]

[1]. Gordhan HM, et al. Eyes on Topical Ocular Disposition: The Considered Design of a Lead Janus Kinase (JAK) Inhibitor That Utilizes a Unique Azetidin-3-Amino Bridging Scaffold to Attenuate Off-Target Kinase Activity, While Driving Potency and Aqueous Solubility. J Med Chem. 2023 Jul 13;66(13):8929-8950.  

Chemical & Physical Properties

[ Molecular Formula ]:
C19H26N8S

[ Molecular Weight ]:
398.53

Related Compounds