PRMT6-IN-3

PRMT6-IN-3 is a selective PRMT6 inhibitor with an IC50 value of 192 nM.PRMT6-IN-3 has anticancer activity and induces apoptosis in cancer cells.

PRMT6-IN-3 (compound 25) (0-40 μM; 72 h) significantly induces apoptosis of cancer cells in a dose-dependent manner. Among them, a concentration of 40 μM could induce apoptosis in 43.44% and 35.08% of HCC827 and MDA-MB-435 cells, respectively.[1]PRMT6-IN-3 (80 μM; 3-7 days) has anti-proliferative activity against HCC827 and MDA-MB-435 cells.[1]

1. Zhang Q, et al. Design, synthesis and evaluation of antitumor activity of selective PRMT6 inhibitors. Eur J Med Chem. 2023;247:115032.