BTK-IN-16
Names
[ CAS No. ]:
2883232-92-4
[ Name ]:
BTK-IN-16
Biological Activity
[Description]:
BTK-IN-16 is a potential inhibitor of wild-type BTK and C481S mutants.BTK-IN-16 can be used to study various autoimmune diseases and cancers caused by BTK.
[In Vivo]
Studies on a mouse model (xid, X-linked immunodeficiency) have revealed the central role of BTK in B-cell BCR signal transduction, differentiation, and survival [1]. Further experiments using BTK-IN-16 on mature B cells suggest the involvement of BTK in B-cell malignancies and models of autoimmune diseases [1].
[References]
1. García-Merino A. Bruton's Tyrosine Kinase Inhibitors: A New Generation of Promising Agents for Multiple Sclerosis Therapy. Cells. 2021 Sep 27;10(10):2560.
Chemical & Physical Properties
[ Molecular Formula ]:
C15H14N4O2
[ Molecular Weight ]:
282.3
Related Compounds
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