5-(3-bromo-4,5-dihydroisoxazol-5-yl)-3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazole

Names

[ Name ]:
5-(3-bromo-4,5-dihydroisoxazol-5-yl)-3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazole

Biological Activity

[Description]:

5-(3-bromo-4,5-dihydroisoxazol-5-yl)-3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazole is a 3-Br-isoxazoline-Based Inhibitors against Plasmodium falciparum (D10 and W2 strains) and Leishmania spp. (L. infantum and L. tropica) Promastigotes with IC50s of 0.035, 0.058, 3.5 and 7.5 μM.

[References]

1. Galbiati A, et al. Development of Potent 3-Br-isoxazoline-Based Antimalarial and Antileishmanial Compounds. ACS Med Chem Lett. 2021 Oct 13;12(11):1726-1732.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₆BrN₃O₂

[ Molecular Weight ]:
350.21

Related Compounds

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