MTL-CEBPA
Names
[ CAS No. ]:
2862057-05-2
[ Name ]:
MTL-CEBPA
Biological Activity
[Description]:
MTL-CEPBA is a small activating RNA targeting for upregulation of C/EBPα. MTL-CEPBA has anti-inflammatory and anti-cancer activity[1].
[Related Catalog]:
[In Vitro]
MTL-CEBPA does not significantly change total human CD45+ cells, and T lymphocytes (hCD4+ and hCD8+ T cell subsets) in PB. However, MTL-CEBPA treatment increases CD16+ granulocytes and CD14+ monocytes in peripheral blood (PB)[1].
[In Vivo]
MTL-CEBPA (iv; 3 mg/kg; on days 1, 3, and 5) demonstrates the specific activation of its target C/EBPα mRNA and its downstream gene p21 in naive hu-NSG mice[1]. MTL-CEBPA restores LPS-induced (12.5 μg; ip; single dose) reduction of C/EBPα and downregulates several genes associated with immune and inflammatory response in an LPS-stimulated humanized NSG model[1].
[References]
Chemical & Physical Properties
No Any Chemical & Physical Properties