RDR03871

Names

[ CAS No. ]:
286008-51-3

[ Name ]:
RDR03871

Biological Activity

[Description]:

RDR03871 (compound 2) is a potent dual MDM2/MDM4 inhibitor with IC50 values of 35.4 nM and 10.4 nM for MDM2-p53 and MDM4-p53, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Apoptosis >> MDM-2/p53

[References]

[1]. Mariateresa Giustiniano, et al. Computer-Aided Identification and Lead Optimization of Dual Murine Double Minute 2 and 4 Binders: Structure-Activity Relationship Studies and Pharmacological Activity. J Med Chem. 2017 Oct 12;60(19):8115-8130.  

Chemical & Physical Properties

[ Molecular Formula ]:
C18H16ClF3N6

[ Molecular Weight ]:
408.81