Antitumor agent-101

Names

[ Name ]:
Antitumor agent-101

Biological Activity

[Description]:

Antitumor agent-101 is a selective covalent inhibitor of lysine methyltransferases G9a/GLP, with IC50s of 8.5 nM and 5.5 nM for G9a and GLP, respectively. Antitumor agent-101 shows antitumor efficacy in the PANC-1 xenograft model[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Histone Methyltransferase

[Target]

G9a:8.5 nM (IC50)

GLP:5.5 nM (IC50)

[References]

[1]. Feng Z, et.al. Structure-Based Design and Characterization of the Highly Potent and Selective Covalent Inhibitors Targeting the Lysine Methyltransferases G9a/GLP. J Med Chem. 2023 Jun 22;66(12):8086-8102.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₃₈N₆O₃

[ Molecular Weight ]:
482.62

Related Compounds

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