Ac9-25 TFA

Names

[ Name ]:
Ac9-25 TFA

[Synonym ]:
DR 4485 hydrochloride

Biological Activity

[Description]:

Ac9-25, a N-terminal peptide of Annexin I, acts as a formyl peptide receptor (FPR) agonist and activates the neutrophil NADPH oxidase through FPR[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Walther A, et al. A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR. Mol Cell. 2000;5(5):831-840.

[2]. Karlsson J, et al. Neutrophil NADPH-oxidase activation by an annexin AI peptide is transduced by the formyl peptide receptor (FPR), whereas an inhibitory signal is generated independently of the FPR family receptors. J Leukoc Biol. 2005;78(3):762-771.

Chemical & Physical Properties

[ Molecular Formula ]:
C₉₉H₁₄₃N₂₃O₃₃

[ Molecular Weight ]:
320.38700

[ Exact Mass ]:
320.18500

[ PSA ]:
117.67000

[ LogP ]:
1.88910

Related Compounds

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