ERD-3111

Names

[ CAS No. ]:
2832865-25-3

[ Name ]:
ERD-3111

Biological Activity

[Description]:

ERD-3111 (Compound 44) is an orally active PROTAC ERα degrader (DC50: 0.5 nM). ERD-3111 inhibits tumor growth in the parental MCF-7 xenograft model with wild-type ER and two clinically relevant ESR1 mutated mice model. ERD-3111 can be used in the research of ER+ breast cancer[1].

[Related Catalog]:

Signaling Pathways >> Others >> Estrogen Receptor/ERR
Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC

[Target]

ERα[1]


[References]

[1]. Chen Z, et al. Discovery of ERD-3111 as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader with Strong Antitumor Activity. J Med Chem. 2023 Aug 30.  

Chemical & Physical Properties

[ Molecular Formula ]:
C45H46F4N8O5

[ Molecular Weight ]:
854.89

Related Compounds

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