TLR7 agonist 14

Names

[ CAS No. ]:
2832199-45-6

[ Name ]:
TLR7 agonist 14

Biological Activity

[Description]:

TLR7 agonist 14 (compound 17b) is a highly potent TLR7 agonist with an EC50 of 18 nM. TLR7 agonist 14 potently induces the activation of mouse macrophages and hPBMCs at low-nanomolar concentrations[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)
Research Areas >> Inflammation/Immunology

[Target]

TLR7:18 nM (IC50)


[References]

[1]. Emma G DeYoung, et al. Synthesis and Optimization of 1-Substituted Imidazo[4,5- c]quinoline TLR7 Agonists. ACS Med Chem Lett. 2023 Sep 14;14(10):1358-1368.  

Chemical & Physical Properties

[ Molecular Formula ]:
C29H36N6O3

[ Molecular Weight ]:
516.63

Related Compounds

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