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Daurinoline

Names

[ CAS No. ]:
2831-75-6

[ Name ]:
Daurinoline

[Synonym ]:
13-Ethyleneacetaldaunomycinone
(1R)-1-[4-(5-{[(1R)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-2-hydroxyphenoxy)benzyl]-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-6-ol
(1R)-1-[4-(5-{[(1R)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-1-isoquinolinyl]methyl}-2-hydroxyphenoxy)benzyl]-7-methoxy-2-methyl-1,2,3,4-tetrahydro-6-isoquinolinol
5,12-Naphthacenedione,7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-1-methoxy-8-(2-methyl-1,3-dioxolan-2-yl)-,(8S-cis)-(9CI)
Daurinoline
Daunomycinone 13-ethylene ketal
6-Isoquinolinol, 1,2,3,4-tetrahydro-1-[[4-[2-hydroxy-5-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]phenoxy]phenyl]methyl]-7-methoxy-2-methyl-, (1R)-

Biological Activity

[Description]:

Daurinoline is an alkaloid that can be isolated from the roots of Menispermum dauricum. Daurinoline may be a potential anti-tumor agent or chemosensitizer for chemo-resistant NSCLC research[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

Daurinoline inhibits the proliferation, migration, invasion and EMT phenotype of chemo-resistant NSCLC cells[1].

[References]

[1]. Dan-Dan Li, et al. Daurinoline suppressed the migration and invasion of chemo-resistant human non-small cell lung cancer cells by reversing EMT and Notch-1 and sensitized the cells to Taxol. Environ Toxicol Pharmacol. 2019 Feb;66:109-115.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
724.5±60.0 °C at 760 mmHg

[ Melting Point ]:
100-103ºC

[ Molecular Formula ]:
C37H42N2O6

[ Molecular Weight ]:
610.739

[ Flash Point ]:
392.0±32.9 °C

[ Exact Mass ]:
610.304260

[ PSA ]:
83.86000

[ LogP ]:
5.84

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.618

[ Storage condition ]:
2-8℃

Related Compounds

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