INDOMETHACIN ESTER, N-HEPTYL-

Names

[ Name ]:
INDOMETHACIN ESTER, N-HEPTYL-

[Synonym ]:
Heptyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate
1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, heptyl ester

Biological Activity

[Description]:

Indomethacin heptyl ester is a selective COX-2 inhibitor with IC50 of 0.04 μM, exhibits anti-inflammatory activity[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> COX

[References]

[1]. A S Kalgutkar, et al. Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. J Med Chem. 2000 Jul 27;43(15):2860-70.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
533.6±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₆H₃₀ClNO₄

[ Molecular Weight ]:
455.97

[ Flash Point ]:
276.5±30.1 °C

[ Exact Mass ]:
455.186340

[ PSA ]:
57.53000

[ LogP ]:
6.75

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.565

Related Compounds

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