PROTAC BTK Degrader-6

Names

[ Name ]:
PROTAC BTK Degrader-6

Biological Activity

[Description]:

PROTAC BTK Degrader-6 (Compound 15) is a PROTAC BTK degrader (DC50: 3.18 nM. PROTAC BTK Degrader-6 has anti-inflammatory activity, inhibits NF-κB activation, and inhibits the expression of pro-inflammatory cytokines (e.g. IL-1β, IL-6)[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk

Signaling Pathways >> PROTAC >> PROTAC

[Target]

3.18 nM (BTK)[1]

[References]

[1]. Huang J, et al. Discovery of Ibrutinib-based BTK PROTACs with in vivo anti-inflammatory efficacy by inhibiting NF-κB activation. Eur J Med Chem. 2023 Jul 18;259:115664.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₅H₄₇N₁₁O₆

[ Molecular Weight ]:
837.92