CD33 splicing modulator 1
Names
[ CAS No. ]:
2762547-05-5
[ Name ]:
CD33 splicing modulator 1
Biological Activity
[Description]:
CD33 splicing modulator 1 is a small-molecule CD33 pre-mRNA splicing modulator with EC50 of 7.8 uM, enhances the exclusion of CD33 exon 2, reduces full-length V-domain containing CD33 protein.CD33/Siglec 3 is a myeloid lineage cell surface receptor that is known to regulate microglia activity.CD33 splicing modulator 1 reduces full-length V-domain containing CD33 protein in meyloid lineage cells (EC50=2.1 uM), increases exon 2 skipping in cellular mRNA pools.
[References]
1. Thomas A Chappie, et al. ACS Med Chem Lett. 2022 Jan 4;13(1):55-62.
Chemical & Physical Properties
[ Molecular Formula ]:
C25H25FN6O
[ Molecular Weight ]:
444.514
Related Compounds
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