Tutuilamide A

Names

[ Name ]:
Tutuilamide A

Biological Activity

[Description]:

Tutuilamide A is a potent porcine pancreatic elastase (PPE) inhibitor, with an IC50 of 1.2 nM. Tutuilamide A also inhibits human neutrophil elastase (HNE; IC50=0.73 nM) and kallikrein 7 (KLK7; IC50=5.0 nM)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Elastase

Research Areas >> Inflammation/Immunology

[Target]

IC50: 1.2 nM (porcine pancreatic elastase), 0.73 nM (human neutrophil elastase), 5.0 nM (kallikrein 7)[1]

[References]

[1]. Chen QY, et, al. Ahp-Cyclodepsipeptides as tunable inhibitors of human neutrophil elastase and kallikrein 7: Total synthesis of tutuilamide A, serine protease selectivity profile and comparison with lyngbyastatin 7. Bioorg Med Chem. 2020 Dec 1;28(23):115756.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₁H₆₉ClN₈O₁₂

[ Molecular Weight ]:
1021.59

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.