Baccatin III

Names

[ Name ]:
Baccatin III

[Synonym ]:
Baccatin III
MFCD00153921
(2α,5β,7β,10β,13α)-4,10-Diacetoxy-1,7,13-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,9,11-trihydroxy-4a,8,13,13-tetramethyl-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-

Biological Activity

[Description]:

Baccatin III is a natural product isolated from Pacific yew tree and related species. Baccatin III reduces tumor progression by inhibiting the accumulation and suppressive function of MDSCs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Lee YH, et al. Baccatin III, a precursor for the semisynthesis of paclitaxel, inhibits the accumulation and suppressive activity of myeloid-derived suppressor cells in tumor-bearing mice. Int Immunopharmacol. 2014 Aug;21(2):487-93.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
713.6±60.0 °C at 760 mmHg

[ Melting Point ]:
229-234 °C

[ Molecular Formula ]:
C₃₁H₃₈O₁₁

[ Molecular Weight ]:
586.627

[ Flash Point ]:
226.9±26.4 °C

[ Exact Mass ]:
586.241394

[ PSA ]:
165.89000

[ LogP ]:
4.06

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.605

[ Storage condition ]:
2-8°C

[ Stability ]:
4 Year Shelf Life

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
R45

[ Safety Phrases ]:
53-22-26-36/37/39-45-24/25

[ RIDADR ]:
1544

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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