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QH536

Names

[ CAS No. ]:
2754254-07-2

[ Name ]:
QH536

Biological Activity

[Description]:

QH536 (Compound 29) is a potent HMGCR degrader with an EC50 of 0.22 μM. QH536 has no side-effect of inducing cholesterol accumulation in cells. QH536 shows anti-inflammatory and can be used for cardiovascular disease and nonalcoholic steatohepatitis research[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR)
Research Areas >> Inflammation/Immunology
Research Areas >> Metabolic Disease

[Target]

IC50: 0.22 μM (HMGCR)[1]


[References]

[1]. Li XZ, et al. Synthesis of heterocyclic ring-fused analogs of HMG499 as novel degraders of HMG-CoA reductase that lower cholesterol. Eur J Med Chem. 2022 Jun 5;236:114323.

Chemical & Physical Properties

[ Molecular Formula ]:
C33H49N3O3

[ Molecular Weight ]:
535.76

Related Compounds