WES-1

Names

[ Name ]:
WES-1

Biological Activity

[Description]:

WES-1 (Compound 8g) is an inhibitor of carbonic anhydrase IX (Ki: 55.9 μM). WES-1 has broad spectrum anti-proliferative activity against the cancer cells, such as leukemia (K-562 and MOLT-4), non-small cell lung cancer (NCI–H460), colon cancer (HCT 116 and HCT-15) and melanoma (LOX IMVI) cell lines[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase

[References]

[1]. Eldehna WM, et al. Design and synthesis of 6-arylpyridine-tethered sulfonamides as novel selective inhibitors of carbonic anhydrase IX with promising antitumor features toward the human colorectal cancer. Eur J Med Chem. 2023 Oct 5;258:115538.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₀N₄O₃S

[ Molecular Weight ]:
396.46

Related Compounds

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