YAP-TEAD-IN-3

Names

[ Name ]:
YAP-TEAD-IN-3

Biological Activity

[Description]:

YAP-TEAD-IN-3 (compound 155) is a YAP/TAZ-TEAD inhibitor. YAP-TEAD-IN-3 inhibits Avi-humanTEAD4217-434 with an IC50 value of 9 nM. YAP-TEAD-IN-3 also inhibits NCI-H2052 with an GI50 of 0.048 μM (cell proliferation)，and an IC50 of 0.048 μM (YAP reporter gene expression)，respsectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Stem Cell/Wnt >> YAP

[Target]

IC50: 9 nM (YAP-TEAD)[1]

[References]

[1]. Bordas V, et al. Preparation of biaryl derivatives as YAP/TAZ-TEAD protein-protein interaction inhibitors. World Intellectual Property Organization, WO2021186324 A1. 2021-09-23.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₂₆ClF₂N₃O₄

[ Molecular Weight ]:
529.96