Influenza virus-IN-7

Names

[ CAS No. ]:
2703046-92-6

[ Name ]:
Influenza virus-IN-7

Biological Activity

[Description]:

Influenza virus-IN-7 (Example 16) is an orally active cap-dependent endonuclease inhibitor that can be used for the research of influenza viral infectious diseases[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Influenza Virus
Research Areas >> Infection

[Target]

IC50: Cap-dependent endonuclease[1]


[In Vitro]

Influenza virus-IN-7 (Example 16) 在 MDCK 细胞中显示出对流感 A/Weiss/43(H1N1) 病毒的抗病毒活性，EC50 为 <5 nM (CC50 >1000 nM)[1]。

[In Vivo]

Influenza virus-IN-7 (Example 16; 5 mg/kg; i.g.; twice daily for 5 days) 可提高 WSN/33 (H1N1) 感染小鼠模型的存活率[1]。 Animal Model: WSN/33 (H1N1) infection mouse model[1] Dosage: 5 mg/kg Administration: Intragastric administration, twice daily for 5 days Result: Significantly improved the survival rate.

[References]

[1]. Wang Shen, et al. Polycyclic pyridopyridazine amide oxime-containing carbocyclic derivatives and uses thereof. Patent CN114315827A.

Chemical & Physical Properties

[ Molecular Formula ]:
C29H26F2N4O7S

[ Molecular Weight ]:
612.60

Related Compounds

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