JAK kinase-IN-1

Names

[ Name ]:
JAK kinase-IN-1

Biological Activity

[Description]:

JAK kinase-IN-1 (Example 1) is a JAK inhibitor. JAK kinase-IN-1 inhibits TYK2, JAK1, JAK2 and JAK3 with IC50 values of 4.2 nM, 32 nM, 27 nM, 3473 nM respectively[1].

[Related Catalog]:

Signaling Pathways >> JAK/STAT Signaling >> JAK

Signaling Pathways >> Epigenetics >> JAK

Signaling Pathways >> Stem Cell/Wnt >> JAK

Research Areas >> Inflammation/Immunology

[References]

[1]. Yao, Yuanshan, et al. Preparation of (pyrimidinyl)thiadiazabicyclo[3.2.1]octane derivatives as JAK kinase inhibitor and used for preventing and/or treating diseases or disorders related to JAK kinase activity or expression. Patent. WO2021180143.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₉F₂N₇OS

[ Molecular Weight ]:
407.44