BBDDL2059

Names

[ Name ]:
BBDDL2059

Biological Activity

[Description]:

BBDDL2059 is a selective covalent inhibitor of histone methyltransferase EZH2 with an IC50 of 1.5 nM for EZH2-Y641F. BBDDL2059 inhibits lymphoma cell growth at nanomolar concentrations and can be used for anticancer research[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Histone Methyltransferase

[Target]

EZH2 Y641F mutant type:1.5 nM (IC50)

[References]

[1]. Zhang Y, et.al. Discovery of a New-Generation S-Adenosylmethionine-Noncompetitive Covalent Inhibitor Targeting the Lysine Methyltransferase Enhancer of Zeste Homologue 2. J Med Chem. 2023 Jun 8;66(11):7629-7644.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₃₆N₄O₄S

[ Molecular Weight ]:
512.66

Related Compounds

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