EBOV/MARV-IN-3

Names

[ Name ]:
EBOV/MARV-IN-3

Biological Activity

[Description]:

EBOV/MARV-IN-3 (compound 32) is a potent EBOV and MARV inhibitor with IC50 values of 0.5, 1.2 µM, respectively. EBOV/MARV-IN-3 binds to the hydrophobic pocket close to EBOV Y517. EBOV/MARV-IN-3 shows antiviral activity[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Filovirus

[Target]

IC50: 0.5 µM (EBOV); 1.2 µM (MARV)[1]

[References]

[1]. Gao Y, et al. Development of coumarine derivatives as potent anti-filovirus entry inhibitors targeting viral glycoprotein. Eur J Med Chem. 2020 Oct 15;204:112595.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₂₉F₃N₂O₆

[ Molecular Weight ]:
534.52