Enpp-1-IN-14

ENPP1-IN-2 is a potent Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) inhibitor with an IC50 value of 32.38 nM for recombinant human ENPP-1. ENPP1-IN-2 has anti-tumor activity[1].

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

IC50: 32.38 nM (recombinant human ENPP-1)[1]

ENPP1-IN-2 (compound 015) (50 mg/kg; IP; BID, for 31 days) significantly inhibits tumor growth[1]. Animal Model: Female C57BL/6 mice (4-6 weeks; implanted subcutaneously with 2×105 MC38 cells)[1] Dosage: 50 mg/kg Administration: IP; BID, for 31 days (given a single 10 Gy exposure of focal radiation to the tumor site) Result: Significantly inhibited tumor growth.

[1]. Srinivas Rao Kasibhatla, et al. Inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 1 (enpp1) and methods of use thereof. WO2021158829A1.