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Coronalolide methyl ester

Names

[ CAS No. ]:
268214-50-2

[ Name ]:
Coronalolide methyl ester

[Synonym ]:
1H-Cyclopenta[7,8]cyclopropa[4,4a]naphtho[2,3-b]furan-10b(2H)-propanoic acid, 4-[(1R,4E)-1,5-dimethyl-6-oxo-4-hexen-1-yl]dodecahydro-3a,6a-dimethyl-10-methylene-9-oxo-, methyl ester, (1aS,3aR,4R,6aS,6bS,7aR,10aR,10bR)-
Methyl 3-[(1aS,3aR,4R,6aS,6bS,7aR,10aR,10bR)-3a,6a-dimethyl-10-methylene-4-[(2R,5E)-6-methyl-7-oxo-5-hepten-2-yl]-9-oxododecahydro-1H-cyclopenta[7,8]cyclopropa[4,4a]naphtho[2,3-b]furan-10b(2H)-yl]propanoate

Biological Activity

[Description]:

Coronalolide methyl ester (NSC 680073) is a natural triterpene with anticancer effects. Coronalolide methyl ester shows moderately cytotoxic to KATO-3, SW-620, and Hep-G2 cells., with IC50 values of 8.64 µg/mL, 6.19 µg/mL, and 6.8 µg/mL, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Thanesuan Nuanyai, et al. Cytotoxic 3,4-seco-cycloartane triterpenes from Gardenia sootepensis. J Nat Prod. 2009 Jun;72(6):1161-4.  

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
607.3±20.0 °C at 760 mmHg

[ Molecular Formula ]:
C31H44O5

[ Molecular Weight ]:
496.678

[ Flash Point ]:
254.5±21.8 °C

[ Exact Mass ]:
496.318878

[ PSA ]:
69.67000

[ LogP ]:
6.42

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.547

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds