Amoxicillin

Names

[ Name ]:
Amoxicillin

[Synonym ]:
Intermox
Lamoxy
A-Gram
Novenzymin
Amoxin
Amoxtrex
AMOX
Amoxa
Imaxilin
Uro-clamoxyl
Imox
Rancil
Moxylin
Ampidroxyl
MOx
Excillin
Tolodina
[2S-[2a,5a,6b(S*)]]-6-[[Amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid
Protexillin
Samosillin
Amoxy
Bridopen
Ranmoxy
Grunamox
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
Jerramcil
Kamoxin
Amoxaren
Zamocillin
Damoxicil
Zamocilline
Larocilin
Cilamox
Amoxy-diolan
Rhamoxilina
Zerrsox
Amoxicillin
Limox
Agerpen
Pasetocin
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(1E,2R)-2-amino-1-hydroxy-2-(4-hydroxyphenyl)ethylidene]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
Gomcillin
Amoxal
Gemox
(2S,5R,6R)-6-{(E)-[(2R)-2-Amino-1-hydroxy-2-(4-hydroxyphenyl)ethylidene]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Sigmopen
Amoxine
Comoxyl
Moxaline
Zimox
amoxil
Bioxidona
blp1410
Amoxi-Diolan
Eupen
Alphamox
Azillin
6-[D(-)-a-Amino-p-hydroxyphenylacetamido]penicillanic Acid
Zamox
Amoxina
Amagesen Solutab
Amoxi-basan
Amoxidal
Amoxillat
Suramox PM
amolin
Amoxisol
Amoxicillin-ratiopharm
Simplamox
Draximox
Amoxihexal
[2S,5R,6R]-6-[[[2R]-Amino[4-hydroxyphenyl]acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid
Optium
Moxlin
Virgoxillin
Trimox
Mopen
EINECS 248-003-8
Clamox
a-Amino-p-hydroxybenzylpenicillin
Amoxibiotic
Meixil
Hipen
Galenamox
Moxilen
Amoxipenil
Farconcil
Rocillin
Amosine
Gimalxina
Ciblor
Zamoxil
Anemol
α-Amino-p-hydroxybenzylpenicillin
Bioxyllin
PENSYN
Triafamox
Moxarin
amoxi
Morgenxil
Amoran
Moxyvit
Grinsul
p-Hydroxyampicillin
Amophar
Amopen
Amodex
(2S,5R,6R)-6-{[(2R)-2-Amino-2-(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Moxypen
Reloxyl
MFCD00072029
Apo-Amoxi
Efpinex
Ikamoxil
Amoxi-wolff
Sil-A-mox
Audumic
Alfamox
Bimox
Fullcilina
Ospamox
Triamoxil
Teramoxyl
Matasedrin
Penbiosyn
Ronemox
Amoxivan
Fisamox
Moxcil
Amoxillin
Winmox
Amcill
Amoxapen
Amoxipen
Pamoxicillin
Amo-flamsian
Abdimox
Biomox
Novabritine
Himinomax
Pacetocin
Posmox
6-(p-Hydroxy-α-aminophenylacetamido)penicillanic acid
Novamoxin
Yisulon
Ranoxyl
Sintopen
Isimoxin
Acimox
Amoxcillin
Samthongcillin
Bintamox
Velamox
Gramidil
clavulanate
Twicyl
Adbiotin
6-(p-Hydroxy-a-aminophenylacetamido)penicillanic Acid
Majorpen
Saltermox
Sia-mox
Izoltil
Amoflux
Utimox
Flemoxine
Imoxil
Paradroxil
Foxolin
Hidramox
Pamocil
Specillin
Kentrocyllin
Senox
Actimoxi
Trilaxin
Superpeni
amoxycillin
(-)-6-[2-Amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid
Bactamox
Medimox
Sawamezin
Dura AX
Maxcil
Apitart
Coamoxin
Hosboral
sumox

Biological Activity

[Description]:

Amoxicillin is a moderate- spectrum, bacteriolytic, β-lactam antibiotic.Target: AntibacterialAmoxicillin is a moderate-spectrum, bacteriolytic, β-lactam antibiotic in the aminopenicillin family used to treat bacterial infections caused by susceptible Gram-positive and Gram-negative microorganisms. It is usually the drug of choice within the class because it is better-absorbed, following oral administration, than other β-lactam antibiotics. Amoxicillin is susceptible to degradation by β-lactamase-producing bacteria, which are resistant to a narrow spectrum of β-lactam antibiotics, such as penicillin. For this reason, it is often combined with clavulanic acid, a β-lactamase inhibitor. This increases effectiveness by reducing its susceptibility to β-lactamase resistance. From Wikipedia.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial

Research Areas >> Infection

[References]

[1]. http://en.wikipedia.org/wiki/Amoxicillin

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
701.8±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₉N₃O₅S

[ Molecular Weight ]:
365.404

[ Flash Point ]:
378.2±35.7 °C

[ Exact Mass ]:
365.104553

[ PSA ]:
158.26000

[ LogP ]:
0.92

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.745

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XH8300000

CHEMICAL NAME :: 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((amino(4-hydroxyphenyl)acetyl) amino)-3,3-dimethyl-7-oxo-

CAS REGISTRY NUMBER :: 26787-78-0

LAST UPDATED :: 199603

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C16-H19-N3-O5-S

MOLECULAR WEIGHT :: 365.44

WISWESSER LINE NOTATION :: T45 ANV ESTJ CMVYZR DQ& F1 F1 GVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 40 mg/kg/4D

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes

REFERENCE :: LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 2,707,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 682 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - urine volume decreased Kidney, Ureter, Bladder - hematuria

REFERENCE :: CPEDAM Clinical Pediatrics (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1962- Volume(issue)/page/year: 32,735,1993

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - hematuria Kidney, Ureter, Bladder - other changes in urine composition

REFERENCE :: CPEDAM Clinical Pediatrics (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1962- Volume(issue)/page/year: 32,735,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >15 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,38,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2870 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,59,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,59,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >25 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,38,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3590 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,59,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,59,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS

REFERENCE :: CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 26,196,1980 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 3 gm/kg

SEX/DURATION :: female 7-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: AGSREJ Arab Gulf Journal of Scientific Research. (Arab Bureau of Education for the Gulf States, POB 3908, Riyadh, 11481, Saudi Arabia) V.7 No.2- 1989- Volume(issue)/page/year: 12,133,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3562 No. of Facilities: 921 (estimated) No. of Industries: 3 No. of Occupations: 11 No. of Employees: 24519 (estimated) No. of Female Employees: 10563 (estimated)

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H317-H334

[ Precautionary Statements ]:
P261-P280-P342 + P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R42/43

[ Safety Phrases ]:
S22-S36/37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
XH8300000

[ HS Code ]:
2941109200

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2941109200

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