Amoxicillin
Names
[ CAS No. ]:
26787-78-0
[ Name ]:
Amoxicillin
[Synonym ]:
Intermox
Lamoxy
A-Gram
Novenzymin
Amoxin
Amoxtrex
AMOX
Amoxa
Imaxilin
Uro-clamoxyl
Imox
Rancil
Moxylin
Ampidroxyl
MOx
Excillin
Tolodina
[2S-[2a,5a,6b(S*)]]-6-[[Amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid
Protexillin
Samosillin
Amoxy
Bridopen
Ranmoxy
Grunamox
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
Jerramcil
Kamoxin
Amoxaren
Zamocillin
Damoxicil
Zamocilline
Larocilin
Cilamox
Amoxy-diolan
Rhamoxilina
Zerrsox
Amoxicillin
Limox
Agerpen
Pasetocin
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(1E,2R)-2-amino-1-hydroxy-2-(4-hydroxyphenyl)ethylidene]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
Gomcillin
Amoxal
Gemox
(2S,5R,6R)-6-{(E)-[(2R)-2-Amino-1-hydroxy-2-(4-hydroxyphenyl)ethylidene]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Sigmopen
Amoxine
Comoxyl
Moxaline
Zimox
amoxil
Bioxidona
blp1410
Amoxi-Diolan
Eupen
Alphamox
Azillin
6-[D(-)-a-Amino-p-hydroxyphenylacetamido]penicillanic Acid
Zamox
Amoxina
Amagesen Solutab
Amoxi-basan
Amoxidal
Amoxillat
Suramox PM
amolin
Amoxisol
Amoxicillin-ratiopharm
Simplamox
Draximox
Amoxihexal
[2S,5R,6R]-6-[[[2R]-Amino[4-hydroxyphenyl]acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid
Optium
Moxlin
Virgoxillin
Trimox
Mopen
EINECS 248-003-8
Clamox
a-Amino-p-hydroxybenzylpenicillin
Amoxibiotic
Meixil
Hipen
Galenamox
Moxilen
Amoxipenil
Farconcil
Rocillin
Amosine
Gimalxina
Ciblor
Zamoxil
Anemol
α-Amino-p-hydroxybenzylpenicillin
Bioxyllin
PENSYN
Triafamox
Moxarin
amoxi
Morgenxil
Amoran
Moxyvit
Grinsul
p-Hydroxyampicillin
Amophar
Amopen
Amodex
(2S,5R,6R)-6-{[(2R)-2-Amino-2-(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Moxypen
Reloxyl
MFCD00072029
Apo-Amoxi
Efpinex
Ikamoxil
Amoxi-wolff
Sil-A-mox
Audumic
Alfamox
Bimox
Fullcilina
Ospamox
Triamoxil
Teramoxyl
Matasedrin
Penbiosyn
Ronemox
Amoxivan
Fisamox
Moxcil
Amoxillin
Winmox
Amcill
Amoxapen
Amoxipen
Pamoxicillin
Amo-flamsian
Abdimox
Biomox
Novabritine
Himinomax
Pacetocin
Posmox
6-(p-Hydroxy-α-aminophenylacetamido)penicillanic acid
Novamoxin
Yisulon
Ranoxyl
Sintopen
Isimoxin
Acimox
Amoxcillin
Samthongcillin
Bintamox
Velamox
Gramidil
clavulanate
Twicyl
Adbiotin
6-(p-Hydroxy-a-aminophenylacetamido)penicillanic Acid
Majorpen
Saltermox
Sia-mox
Izoltil
Amoflux
Utimox
Flemoxine
Imoxil
Paradroxil
Foxolin
Hidramox
Pamocil
Specillin
Kentrocyllin
Senox
Actimoxi
Trilaxin
Superpeni
amoxycillin
(-)-6-[2-Amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid
Bactamox
Medimox
Sawamezin
Dura AX
Maxcil
Apitart
Coamoxin
Hosboral
sumox
Biological Activity
[Description]:
[Related Catalog]:
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.6±0.1 g/cm3
[ Boiling Point ]:
701.8±70.0 °C at 760 mmHg
[ Molecular Formula ]:
C16H19N3O5S
[ Molecular Weight ]:
365.404
[ Flash Point ]:
378.2±35.7 °C
[ Exact Mass ]:
365.104553
[ PSA ]:
158.26000
[ LogP ]:
0.92
[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C
[ Index of Refraction ]:
1.745
[ Storage condition ]:
2-8°C
[ Stability ]:
Stable. Incompatible with strong oxidizing agents.
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XH8300000
- CHEMICAL NAME :
- 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((amino(4-hydroxyphenyl)acetyl) amino)-3,3-dimethyl-7-oxo-
- CAS REGISTRY NUMBER :
- 26787-78-0
- LAST UPDATED :
- 199603
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C16-H19-N3-O5-S
- MOLECULAR WEIGHT :
- 365.44
- WISWESSER LINE NOTATION :
- T45 ANV ESTJ CMVYZR DQ& F1 F1 GVQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 40 mg/kg/4D
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes
- REFERENCE :
- LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 2,707,1978
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - child
- DOSE/DURATION :
- 682 mg/kg
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - urine volume decreased Kidney, Ureter, Bladder - hematuria
- REFERENCE :
- CPEDAM Clinical Pediatrics (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1962- Volume(issue)/page/year: 32,735,1993
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - child
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - hematuria Kidney, Ureter, Bladder - other changes in urine composition
- REFERENCE :
- CPEDAM Clinical Pediatrics (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1962- Volume(issue)/page/year: 32,735,1993
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >15 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,38,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2870 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,59,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >8 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,59,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >25 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,38,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3590 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,59,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >20 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,59,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intracerebral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >500 mg/kg
- TOXIC EFFECTS :
- Brain and Coverings - recordings from specific areas of CNS
- REFERENCE :
- CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 26,196,1980 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 3 gm/kg
- SEX/DURATION :
- female 7-12 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- REFERENCE :
- AGSREJ Arab Gulf Journal of Scientific Research. (Arab Bureau of Education for the Gulf States, POB 3908, Riyadh, 11481, Saudi Arabia) V.7 No.2- 1989- Volume(issue)/page/year: 12,133,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3562 No. of Facilities: 921 (estimated) No. of Industries: 3 No. of Occupations: 11 No. of Employees: 24519 (estimated) No. of Female Employees: 10563 (estimated)
Safety Information
[ Symbol ]:
GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H317-H334
[ Precautionary Statements ]:
P261-P280-P342 + P311
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ Hazard Codes ]:
Xn:Harmful
[ Risk Phrases ]:
R42/43
[ Safety Phrases ]:
S22-S36/37
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
2
[ RTECS ]:
XH8300000
[ HS Code ]:
2941109200
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2941109200
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