(S)-(-)-2-Bromo-3-methylbutyric acid

Names

[ Name ]:
(S)-(-)-2-Bromo-3-methylbutyric acid

[Synonym ]:
MFCD00210114
α-BROMOISOVALERIC ACID, (S)-
(2S)-2-bromo-3-methyl-butanoic acid
2-Bromo-3-methylbutyric acid
Butanoic acid, 2-bromo-3-methyl-
2S-2-bromo-3-methylbutanoic acid
(2S)-2-Bromo-3-methylbutanoic acid
α-Bromoisovaleric acid
(±)-2-BROMO-3-METHYLBUTYRIC ACID
(S)-2-Bromoisovaleric acid
Isovaleric acid, α-bromo-
2-Bromo-3-methylbutanoic acid
(S)-2-Bromo-3-methylbutyric acid
Butanoic acid, 2-bromo-3-methyl-, (2S)-
(S)-(-)-2-Bromo-3-methylbutyric acid
S-2-Bromo-3-methyl-butyric acid
UNII:M69LGV465C

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
230.0±0.0 °C at 760 mmHg

[ Melting Point ]:
39-44ºC

[ Molecular Formula ]:
C₅H₉BrO₂

[ Molecular Weight ]:
181.028

[ Flash Point ]:
107.2±0.0 °C

[ Exact Mass ]:
179.978592

[ PSA ]:
37.30000

[ LogP ]:
1.73

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.487

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H312-H314-H332

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C: Corrosive;

[ Risk Phrases ]:
R20/21/22;R34

[ Safety Phrases ]:
S26-S27-S28-S36/37/39-S45

[ RIDADR ]:
UN 3261

[ HS Code ]:
2915900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2915900090

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

Articles

Glutathione conjugation of the alpha-bromoisovaleric acid enantiomers in the rat in vivo and its stereoselectivity. Pharmacokinetics of biliary and urinary excretion of the glutathione conjugate and the mercapturate.

Biochem. Pharmacol. 38(22) , 3957-62, (1989)

The glutathione (GSH) conjugation of (R)-and (S)-alpha-bromoisovaleric acid (BI) in the rat in vivo, and its stereoselectivity, have been characterized. After administration of racemic [1-14C]BI two r...

Stereoselectivity of rat liver glutathione transferase isoenzymes for alpha-bromoisovaleric acid and alpha-bromoisovalerylurea enantiomers.

Biochem. J. 252(1) , 137-42, (1988)

The stereoselectivity of purified rat GSH transferases towards alpha-bromoisovaleric acid (BI) and its amide derivative alpha-bromoisovalerylurea (BIU) was investigated. GSH transferase 2-2 was the on...

Stereoselective conjugation of 2-bromocarboxylic acids and their urea derivatives by rat liver glutathione transferase 12-12 and some other isoforms.

Biochem. Pharmacol. 44(7) , 1249-53, (1992)

Glutathione (GSH) conjugation of the separate enantiomers of five 2-bromocarboxylic acids and some of their urea derivatives by rat liver GSH transferases (GSTs) was studied. The liver cytosolic fract...