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Bcl-2/Mcl-1-IN-1

Names

[ CAS No. ]:
2673361-08-3

[ Name ]:
Bcl-2/Mcl-1-IN-1

Biological Activity

[Description]:

Bcl-2/Mcl-1-IN-1 (compound 3) is a Bcl-2/Mcl-1 inhibitor, with Kis of 1.19 μM and 4.53 μM for Mcl-1 and Bcl-2, respectively. Bcl-2/Mcl-1-IN-1 can be used for the research of cancer[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family
Research Areas >> Cancer

[Target]

Mcl-1:1.19 μM (Ki)

Bcl-2:4.53 μM (Ki)


[References]

[1]. Niu Q, et, al. Design, synthesis and biological evaluation of dual Bcl-2/Mcl-1 inhibitors bearing 2-(1H-indol-4-yl)benzoic acid scaffold. Bioorg Med Chem Lett. 2021 Sep 1;47:128215.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H23NO3

[ Molecular Weight ]:
421.49

Related Compounds