AL-470

Names

[ Name ]:
AL-470

Biological Activity

[Description]:

AL-470 is a potent antiviral agent with EC50 values of 0.27, 0.63, and 0.35 µM against HIV-1, HIV-2, and EV-A71, respectively[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

[Target]

HIV-1:0.27 μM (EC50)

HIV-2:0.63 μM (EC50)

EV-A71:0.35 μM (EC50)

[In Vitro]

AL-470 shows antiviral activity against the whole panel of mutant EV-A71 strains: EV-A71 BrCr wt (EC50 = 0.3 ± 0.03 µM), VP1_S184T (EC50 = 2.3 ± 0.6 µM), VP1_P246S (EC50 = 1.9 ± 0.04 µM), VP1_S184T_P246S (EC50 = 2.2 ± 0.08 µM)[1].

[References]

[1]. Olaia Martí-Marí, et al. Organotropic dendrons with high potency as HIV-1, HIV-2 and EV-A71 cell entry inhibitors. Eur J Med Chem. 2022 Jul 5;237:114414.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆₇H₅₇N₇O₂₃

[ Molecular Weight ]:
1328.20

Related Compounds

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