PROTAC MEK1 Degrader-1

Names

[ CAS No. ]:
2671004-41-2

[ Name ]:
PROTAC MEK1 Degrader-1

Biological Activity

[Description]:

PROTAC MEK1 Degrader-1 is a PROTAC targeting MEK1 with a pIC50 value of 7.0. PROTAC MEK1 Degrader-1 consists of a MEK1 inhibitor and a von Hippel-Lindau ligand. PROTAC MEK1 Degrader-1 can inhibit ERK1/2 phosphorylation. PROTAC MEK1 Degrader-1 shows an antiproliferative activity against A375 cells[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> MAPK/ERK Pathway >> MEK
Signaling Pathways >> PROTAC >> PROTAC
Signaling Pathways >> MAPK/ERK Pathway >> ERK
Signaling Pathways >> Stem Cell/Wnt >> ERK

[References]

[1]. Vollmer S, et al. Design, Synthesis, and Biological Evaluation of MEK PROTACs. J Med Chem. 2020 Jan 9;63(1):157-162.  

Chemical & Physical Properties

[ Molecular Formula ]:
C53H66FIN8O11S2

[ Molecular Weight ]:
1201.17

Related Compounds