URAT1&XO inhibitor 1

Names

[ CAS No. ]:
2669726-78-5

[ Name ]:
URAT1&XO inhibitor 1

Biological Activity

[Description]:

URAT1&XO inhibitor 1 (compound 29) is a dual inhibitor of both URAT1 (IC50=~10 μM) and Xanthine Oxidase (IC50=1.01 μM). URAT1&XO inhibitor 1 results hypouricemic effect in potassium oxonate-induced hyperuricemia rat model. URAT1&XO inhibitor 1 is used for hyperuricemia research[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> URAT1
Research Areas >> Metabolic Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> Xanthine Oxidase

[References]

[1]. Fengwei Lin, et al. Identification of 5-[5-cyano-1-(pyridin-2-ylmethyl)-1H-indole-3-carboxamido] thiazole-4-carboxylic acid as a promising dual inhibitor of urate transporter 1 and xanthine oxidase. European Journal of Medicinal Chemistry. Volume 257, 5 September 2023, 115532.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H13N5O3S

[ Molecular Weight ]:
403.41

Related Compounds

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