vMIP-II (1-21)

Names

[ CAS No. ]:
265650-93-9

[ Name ]:
vMIP-II (1-21)

Biological Activity

[Description]:

vMIP-II (1-21) is a CXCR4 antagonist. vMIP-II has broad-spectrum interaction with CC and CXC chemokine receptors. vMIP-II (1-21) binds with CXCR4 with an IC50 value of 190 nM for competing with CXCR4 binding of 125I-SDF-1R[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> CXCR
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> CXCR

[In Vitro]

vMIP-II (1-21) (0.01-10 μM) 可与趋化因子受体 CXCR4 结合[1]。 vMIP-II (1-21) (25-200 μM) 抑制 CXCR4 介导 T 和双亲性 HIV-1 gp120 介导的细胞-细胞融合[1]。 vMIP-II (1-21) (100 μM) 剂量依赖性地抑制的趋化活性[1]。

[References]

[1]. Zhou N, ey al. A novel peptide antagonist of CXCR4 derived from the N-terminus of viral chemokine vMIP-II. Biochemistry. 2000 Apr 4;39(13):3782-7.  

Chemical & Physical Properties

[ Molecular Formula ]:
C108H169N33O27S

[ Molecular Weight ]:
2425.84

Related Compounds