KM04416

KM04416, an isothiazolone derivative, is a potent glycerol-3-phosphate dehydrogenase (GPD2) inhibitor. KM04416 significantly inhibits PNT1A cell proliferation[1][2].

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

KM04416 (20 µM; 48 小时) 对多种癌细胞系具有生长抑制作用[1]。 KM04416 (10 µM; 72小时) 显着抑制 PNT1A 细胞增殖[1]。 Cell Viability Assay[1] Cell Line: Several cancer cell lines including MDA-MB-231 and AsPC-1 as well as Huh-7, HepG2, and SK-HEP-1 cells Concentration: 20 µM Incubation Time: 48 h Result: Had a growth inhibitory effect. Cell Proliferation Assay[2] Cell Line: PNT1A cell Concentration: 10 µM Incubation Time: 72 h Result: Significantly inhibited PNT1A cell proliferation.

[1]. Sehyun Oh, et al. Non-bioenergetic roles of mitochondrial GPD2 promote tumor progression. Theranostics. 2023 Jan 1;13(2):438-457.  

[2]. Gurmit Singh, et al. Mitochondrial FAD-linked Glycerol-3-phosphate Dehydrogenase: A Target for Cancer Therapeutics. Pharmaceuticals (Basel). 2014 Feb 11;7(2):192-206.