GNE-7883

Names

[ CAS No. ]:
2648450-42-2

[ Name ]:
GNE-7883

Biological Activity

[Description]:

GNE-7883 is a pan-TEAD inhibitor with anti-cell proliferation activity. GNE-7883 overcomes resistance to KRAS G12C inhibitors in multiple preclinical models by inhibiting YAP/TAZ activation. GNE-7883 may be used in the study of YAP/TAZ-dependent cancers[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Stem Cell/Wnt >> YAP

[Target]

TEAD[1].


[References]

[1]. Hagenbeek TJ, et al. An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance. Nat Cancer. 2023 Jun;4(6):812-828.  

Chemical & Physical Properties

[ Molecular Formula ]:
C28H29FN6O2

[ Molecular Weight ]:
500.57