Pomalidomide-C11-NH2

Names

[ CAS No. ]:
2648285-39-4

[ Name ]:
Pomalidomide-C11-NH2

Biological Activity

[Description]:

Pomalidomide-C11-NH2 is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-C11-NH2 can be connected to the ligand for protein by a linker to form PROTAC[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[References]

[1]. Chotitumnavee J, et al. Selective degradation of histone deacetylase 8 mediated by a proteolysis targeting chimera (PROTAC). Chem Commun (Camb). 2022 Apr 7;58(29):4635-4638.  

Chemical & Physical Properties

[ Molecular Formula ]:
C24H34N4O4

[ Molecular Weight ]:
442.55

Related Compounds

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