6',7'-Dihydroxybergamottin

Names

[ Name ]:
6',7'-Dihydroxybergamottin

[Synonym ]:
7H-Furo[3,2-g][1]benzopyran-7-one, 4-[[(2E,6R)-6,7-dihydroxy-3,7-dimethyl-2-octen-1-yl]oxy]-
4-{[(2E,6R)-6,7-Dihydroxy-3,7-dimethyl-2-octen-1-yl]oxy}-7H-furo[3,2-g]chromen-7-one

Biological Activity

[Description]:

(R)-6',7'-Dihydroxybergamottin ((R)-6′,7′-DHB) is a competitive inhibitor of human and rat CYP1A1 activity with Kis of 55 μM and 1.72 μM, respectively. (R)-6',7'-Dihydroxybergamottin has the potential for cancer research[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

[References]

[1]. Rebeca Santes-Palacios, et al. Inhibition of human and rat CYP1A1 enzyme by grapefruit juice compounds. Toxicol Lett. 2016 Sep 6:258:267-275.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
578.2±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₄O₆

[ Molecular Weight ]:
372.412

[ Flash Point ]:
303.5±30.1 °C

[ Exact Mass ]:
372.157288

[ PSA ]:
93.04000

[ LogP ]:
2.67

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.601

Safety Information

[ Hazard Codes ]:
Xi

Precursor & DownStream

Precursor

DownStream

Related Compounds

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