PAD4-IN-2

Names

[ CAS No. ]:
2642327-52-2

[ Name ]:
PAD4-IN-2

Biological Activity

[Description]:

PAD4-IN-2 (compound 5i) is a PAD4 inhibitor (IC50=1.94 μM). PAD4-IN-2 inhibits tumor growth in mice by specifically inhibiting the PAD4-H3cit-NETs pathway in neutrophils[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> Protein Arginine Deiminase

[Target]

IC50: 1.94 μM (PAD4)[1].


[References]

[1]. Zhu D, et al. Highly-tumor-targeted PAD4 inhibitors with PBA modification inhibit tumors in vivo by specifically inhibiting the PAD4-H3cit-NETs pathway in neutrophils. Eur J Med Chem. 2023 Oct 5;258:115619.  

Chemical & Physical Properties

[ Molecular Formula ]:
C20H23BClN7O6

[ Molecular Weight ]:
503.70

Related Compounds