PTD10

Names

[ Name ]:
PTD10

Biological Activity

[Description]:

PTD10 is a highly potent PROTAC BTK degrader (DC50: 0.5 nM, KD: 2.28 nM). PTD10 degrades BTK in Ramos and JeKo-1 cells with DC50s of 0.5 and 0.6 nM respectively. PTD10 inhibits cell growth, and induces cell apoptosis via activation of the caspase-dependent pathway and mitochondrial pathway. PTD10 can be used for research of B-cell dysregulation[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk

Signaling Pathways >> PROTAC >> PROTAC

[References]

[1]. Li YQ, et al. Discovery of Novel Bruton's Tyrosine Kinase PROTACs with Enhanced Selectivity and Cellular Efficacy. J Med Chem. 2023 Jun 8;66(11):7454-7474.

[2]. Li YQ, et, al. Discovery of Novel Bruton's Tyrosine Kinase PROTACs with Enhanced Selectivity and Cellular Efficacy. J Med Chem. 2023 Jun 8;66(11):7454-7474.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₉H₅₁N₁₁O₈

[ Molecular Weight ]:
922.00

Related Compounds

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