RIG012

Names

[ Name ]:
RIG012

Biological Activity

[Description]:

RIG012 is a potent RIG-I inhibitor with an IC50 of 0.71 μM using the NADH-coupled ATPase assay. RIG012 inhibits IFN-β and ISG hRsad2 expression[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Others >> Others

[In Vitro]

RIG012 包含在可见光范围内吸收的强生色团 (λmax 为 470 nm)。与 RIG-I 结合后，RIG012 的 470 nm 吸收带发生显着的增色转变，向更高的强度值转变[1]。 RIG012 (1, 1.25, 1.5, 2, 2.5, 3, 4 μM) 在与表达质粒和报告质粒共转染的 HEK293T 细胞中对 RIG-I 信号传导具有有效的剂量依赖性抑制作用[1]。 RIG012 (1.25, 2.25, 4.5, 9, 18 μM) 对 A549 细胞中的 IFN-β 和 ISG hRsad2 表达具有有效的剂量依赖性抑制作用[1]。

[References]

[1]. David C Rawling, et al. Small-Molecule Antagonists of the RIG-I Innate Immune Receptor. ACS Chem Biol. 2020 Feb 21;15(2):311-317.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₁NO₃

[ Molecular Weight ]:
359.42

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.