RMC-4998

Names

[ CAS No. ]:
2642037-07-6

[ Name ]:
RMC-4998

Biological Activity

[Description]:

RMC-4998 is a molecular glue compound with good antitumor activity. RMC-4998 is able to form a ternary complex with CYPA and an activated KRAS G12C mutant. Furthermore, CYPA binding to KRAS G12C blocks the interaction between activated KRAS mutants and downstream effector proteins, thereby inhibiting signaling that promotes cell proliferation[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Ras

[References]

[1]. Christopher J Schulze, et al. Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS. Science. 2023 Aug 18;381(6659):794-799.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₇H₇₄N₈O₇

[ Molecular Weight ]:
983.25

Related Compounds

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