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(12Z)-9,10-Dihydroxy-12-octadecenoic acid

Names

[ CAS No. ]:
263399-34-4

[ Name ]:
(12Z)-9,10-Dihydroxy-12-octadecenoic acid

[Synonym ]:
12-Octadecenoic acid, 9,10-dihydroxy-, (9R,10R,12Z)-
leukotoxin diol
12-Octadecenoic acid, 9,10-dihydroxy-, (12Z)-
(9R,10R,12Z)-9,10-Dihydroxy-12-octadecenoic acid
(12Z)-9,10-Dihydroxy-12-octadecenoic acid

Biological Activity

[Description]:

(±)9,10-DiHOME is the racemate of 9,10-DiHOME. 9,10-DiHOME is a leukotoxin derivative of linoleic acid diol that has been reported to be toxic in human's tissue preparations, and is produced by inflammatory leukocytes such as neutrophils and macrophages[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[References]

[1]. Nieman DC, et al. Influence of pistachios on performance and exercise-induced inflammation, oxidative stress, immune dysfunction, and metabolite shifts in cyclists: a randomized, crossover trial. PLoS One. 2014;9(11):e113725. Published 2014 Nov 19.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
491.8±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H34O4

[ Molecular Weight ]:
314.460

[ Flash Point ]:
265.3±22.4 °C

[ Exact Mass ]:
314.245697

[ PSA ]:
77.76000

[ LogP ]:
4.14

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.493

[ Storage condition ]:
-20°C

Related Compounds