ZK824190 hydrochloride

Names

[ Name ]:
ZK824190 hydrochloride

Biological Activity

[Description]:

ZK824190 hydrochloride is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> PAI-1

Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease

Research Areas >> Inflammation/Immunology

[In Vivo]

ZK824190 (2 mg/kg; PO; Rats with EAE model) exhibits a relatively high oral availability and a moderate half time (T1/2=2.8 h)[1].

[References]

[1]. Islam I, et al. Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3372-3375.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₁ClF₂N₂O₄

[ Molecular Weight ]:
450.86

Related Compounds

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