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9(S)-Erythromycylamine

Names

[ CAS No. ]:
26116-56-3

[ Name ]:
9(S)-Erythromycylamine

[Synonym ]:
MFCD00872156

Biological Activity

[Description]:

Erythromycylamine is a macrolide antibiotic. Erythromycylamine has antibacterial activity against most Gram-positive cocci and M. catarrhalis[1][2].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Naik S, et al. In vitro activities of several new macrolide antibiotics against Mycobacterium avium complex. Antimicrob Agents Chemother. 1989 Sep;33(9):1614-6.  

[2]. Fernandes CJ, et al. Multi-centre collaborative study for the in vitro evaluation of new macrolides dirithromycin and erythromycylamine. Australian Group for Antimicrobial Resistance (AGAR). Pathology. 1995 Jan;27(1):74-8.  

Chemical & Physical Properties

[ Density]:
1.19g/cm3

[ Boiling Point ]:
810.3ºC at 760mmHg

[ Molecular Formula ]:
C37H70N2O12

[ Molecular Weight ]:
734.96

[ Flash Point ]:
443.8ºC

[ Exact Mass ]:
734.49300

[ PSA ]:
202.86000

[ LogP ]:
2.24410

[ Vapour Pressure ]:
2.15E-30mmHg at 25°C

[ Index of Refraction ]:
1.539

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KF4590000
CHEMICAL NAME :
Erythromycin, 9-amino-9-deoxo-, stereoisomer
CAS REGISTRY NUMBER :
26116-56-3
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C37-H70-N2-O12
MOLECULAR WEIGHT :
735.09

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 13,83,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
120 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 13,83,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
57500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 13,83,1978

Safety Information

[ Hazard Codes ]:
Xi,N

[ Risk Phrases ]:
41-50/53

[ Safety Phrases ]:
26-39-60-61

Precursor & DownStream

Precursor

DownStream

Related Compounds