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Topilutamide

Names

[ CAS No. ]:
260980-89-0

[ Name ]:
Topilutamide

[Synonym ]:
UNII-A8EU2FXY13
2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-(2,2,2-trifluoroacetylamino)propanamide
Topilutamide

Biological Activity

[Description]:

Topilutamide is a topical nonsteroidal antiandrogen (NSAA).

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Cancer

[In Vivo]

Prostate cancer is the most common cancer and one of the leading causes of cancer deaths in men. One of the commonly used approaches to treat metastatic prostate cancer is via first-generation nonsteroidal anti-androgens (NSAAs), namely Flutamide, Nilutamide, Bicalutamide and Topilutamide[1].

[References]

[1]. Suresh PS, et al. Review of HPLC and LC-MS/MS assays for the determination of various nonsteroidal anti-androgens used in the treatment of prostate cancer. Biomed Chromatogr. 2017 Jun 21.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Molecular Formula ]:
C13H11F6N3O5

[ Molecular Weight ]:
403.23400

[ Exact Mass ]:
403.06000

[ PSA ]:
131.23000

[ LogP ]:
3.99460

[ Storage condition ]:
2-8℃

Related Compounds

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